Seminar 2006 11 15 Cellular Therapy
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CISST ERC Seminar
Targeted Cellular Therapy with MRI
Date: Wednesday, November 15, 2006
Time: 12:00pm, Lunch will be served before the seminar.
Place: Maryland Hall 110
Speaker: Aravind Arepally
Hopkins Radiology
Title: Targeted Cellular Therapy with Magnetic Resonance Imaging
Presentation slideshow: PDF, 60MB ( info )
Abstract:
Magnetic resonance imaging (MRI) provides an unexplored alternative to conventional x-ray approaches for image guided therapies due to superior soft tissue resolution and multiplanar capability. Interventional MR refers to catheter-based procedures that utilize MRI rather than conventional fluoroscopic guidance. Interventional MR suites (XMR), which combine x-ray DSA with adjunctive MRI scanners, now allow for real-time interventional procedures to be performed in a clinical setting.
In these XMR suites, x-ray fluoroscopy is used to guide catheter placement, and subsequently, the patient can be moved directly into an MRI for adjunctive imaging. The capability to fuse previously acquired three-dimensional anatomic MR imaging during procedures and iteratively monitor the functional outcome of therapy provides unparalleled advantages.
Our research efforts are a multidisciplinary collaboration between the Division of Interventional Radiology, Institute for Cellular Engineering, Biomedical Engineering and MR Research Division. Through the development of novel labeling and encapsulation techniques, we have developed methods to label, deliver and monitor cellular therapy using only MRI. With these advances, immediate potential clinical applications are for stem cell therapies and islet cell transplantation.
Bio:
Dr. Aravind Arepally is an Assistant Professor of Radiology and Surgery at the Johns Hopkins University School of Medicine. Dr. Arepally obtained his undergraduate degree from the Mercer University with a degree in Mathematics. He subsequently graduated from the Emory University School of Medicine in 1993. He received his diagnostic radiology training at Emory University Hospital. He continued his training at Johns Hopkins Medical Institutes where he was a fellow in Cardiovascular and Interventional Radiology. Upon completion of his training, he joined the department as full time faculty in 2000.
His research interests include basic science research, clinical research, and device development. In the basic science arena, he is investigating the use of MRI to perform cellular delivery and tracking. He hopes to be able to develop new therapies such as Islet Cell Transplantation utilizing MRI.
His clinical research interests include problems related to the cardiovascular system, in particular, the treatment of vascular disease. He is also working with the Johns Hopkins School of Biomedical Engineering and Division of MR Research on projects related to new minimally invasive devices.